Dose-independent occurrence of seizure with tramadol

Tramadol Induced Seizure: Report of 106 Patients

Background: Seizure is one of the possible adverse effects of tramadol hydrochloride, a synthetic, centrallyacting analgesic, prescribed for the treatment of moderate to severe pain. In this study, we describe 106 patients with tramadol induced seizures. Methods: The patients, who were referred to Nemazee Hospital, Shiraz, Iran, from March 2006 to March 2008, were examined in this cross-section...

Seizure and Rhabdomyolysis: Serious Complications of Tramadol Overdose

To the Editor; Tramadol, a synthetic opioid is mainly used to treat acute and chronic pain. Although this drug is not an over-the-counter medication, it has been illicitly accessible to and abused by opium addicts (1-3). Studies showed excessive and widespread use of tramadol in Iran (1-4). Tramadol may cause constipation, drowsiness, tachycardia and respiratory distress, while the most severe...

Intravenous Tramadol-Induced Seizure: Two Case Reports

There are a few reports of seizure induced by tramadol at therapeutic dose. Two case reports of repeated seizures with following agitation due to treatment with tramadol are presented here. Both of them have similar presentation and tramadol was injected intravenously at therapeutic doses. Tramadol prescription especially intravenously can evoke seizure with agitation or even status epilepticus...

Tramadol induced seizure. Is Isoniazid the culprit?

Tramadol induced seizure: A 3-year study

Background: Tramadol is a synthetic analgesic. Seizures have been reported in patients receiving this drug. In this study we evaluated the correlation between tramadol consumption and seizure occurrence. Methods: Twenty-eight subjects with a history of tramadol consumption and seizure were studied. Electroencephalograms (EEG) were performed in the first 24 hours and again one week later. Subje...